Mediator of ErbB2-driven cell motility 1 （MEMO1） is a member of the UPF0103 family. MEMO1 regulates cell migration by transmitting extracellular chemotactic signals to the microtubule cytoskeleton. Furthermore， MEMO1 controls the localization of APC and CLASP2 to the cell membrane， using the regulation of GSK3B activity. MEMO1 is essential for breast carcinoma cell migration， suggesting a key role in tumorigenesis. MEMO1 is also a mediator of ERBB2 signaling.
