Transcription Elongation Factor A （SII）-Like 7 （TCEAL7） has a role in the negative regulation of NF-kappa-B signaling at the basal level by controlling transcriptional activity of NF-kappa-B on its target gene promoters. TCEAL7 links with cyclin D1 promoter containing Myc E-box sequence and transcriptionally inhibits cyclin D1 expression. TCEAL7 regulates telomerase reverse transcriptase expression and telomerase activity in both alternative lengthening of telomeres （ALT） and telomerase-positive cell lines. TCEAL7 is highly expressed in normal and fetal brain tissues， and weakly expressed in the uterus and ovary. TCEAL7 is down-regulated in epithelial ovarian， cervical， prostate， breast， brain and lung cancer cell lines and in the brain and ovarian tumors.
