Clathrin， light chain A （CLTA） is a member of the clathrin family. Clathrin， which is a large， soluble protein， is comprised of heavy and light chains. CLTA is one of 2 clathrin light chain proteins which are supposed to function as regulatory elements. CLTA is a key cytosolic coat protein in pits and vesicles originating from the plasma membrane and the trans-Golgi network. In receptor-mediated endocytosis， receptor proteins are encapsulated by Clathrin-coated vesicles.
