TBCB is a member of the Microtubules family. Biosynthesis of functional microtubules include the involvement of a number of chaperones， termed Tubulin folding cofactors A （TBCA）， B （TBCB）， C （TBCC）， D （TBCD） and E （TBCE）， which operate on folding intermediates downstream of the cytosolic chaperon， known as TCP. The 244 amino acid cytoplasmic protein TBCB has one CAP-Gly domain and is universally expressed. TBCB takes part in the regulation of tubulin heterodimer dissociation and operates as a negative regulator of axonal growth.
