Charged multivesicular body protein 1b （CHMP1B） is a member of the chromatin-modifying protein/charged multivesicular body protein （CHMP） family. CHMP1B is a possible peripherally associated component of the ESCRT-III （endosomal sorting required for transport complex III） which is involved in MVBs （multivesicular bodies） formation and sorting of endosomal cargo proteins into MVBs. The MVBs contain ILVs （intraluminal vesicles） which are created by invagination and scission from the limiting membrane of the endosome and generally are transported to lysosomes enabling degradation of membrane proteins， such as stimulated growth factor receptors， lysosomal enzymes and lipids.
