Charged multivesicular body protein 6 （CHMP6） is a member of the SNF7 family. The CHMP6 protein is a core component of the endosomal sorting necessary for transport complex III （ESCRT-III） that is involved in multivesicular bodies （MVBs） formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles （ILVs） which are produced by invagination and scission from the limiting membrane of the endosome and generally are transported to lysosomes facilitating degradation of membrane proteins， such as stimulated growth factor receptors， lysosomal enzymes and lipids.
