VPS29 is a member of a group of genes coding for vacuolar protein sorting （VPS） proteins which， when functionally damaged， lessens the efficient transfer of vacuolar hydrolases. VPS29 is a late Golgi transmembrane protein that operates as the sorting receptor for soluble vacuolar hydrolases， from the prevacuolar endosome back to the Golgi. Moreover， VPS29 takes part in the creation of the inner shell of the retromer coat for retrograde vesicles parting the prevacuolar compartment.
