BCL10 holds a caspase recruitment domain （CARD）， and is known as an inducer of apoptosis and as NF-kappaB activator. BCL10 cooperates with other CARD domain containing proteins such as CARD9， 10， 11 and 14， which operates as upstream regulators in NF-kappaB signaling. BCL10 is known to create a complex with MALT1， a protein encoded by another gene and is translocated in MALT lymphoma. MALT1 and BCL10 protein synergize the activation of NF-kappaB， and the deregulation of either of them facilitates the same pathogenetic process which leads to the malignancy.
