Nuclear transport factor 2-like export factor 2 （NXT2） belongs to the NXT family proteins which are commonly involved in exporting nuclear RNA in eukaryotic cells. The NXT2 protein is a regulator of protein export for NES-containing proteins. In addition， NXT2 associates with NXF1， NXF2， NXF3 and NXF5 and has a role in mRNA nuclear export. NXT2 has a critical role in upholding morphogenetic integrity of embryonic heart in vertebrate species. The NXT2 protein contains a nuclear transport factor 2 （NTF2） domain， which has a vital role in the trafficking of macromolecules， ions， and small molecules between the cytoplasm and nucleus， it may also have a role in mRNA nuclear export.
