Vps20-associated 1 homolog （VTA1） is a member of the VTA1 family. The VTA1 protein is involved in the endosomal multivesicular bodies （MVB） pathway. Furthermore， VTA1 is interacts with CHMP1B， CHMP2A， CHMP5， VPS4B， KIAA0174 （IST1） and possibly CHMP3. VTA1 is believed to be a cofactor of VPS4A/B， which catalyzes membrane-associated ESCRT-III assemblies. In addition， VTA1 is involved in the sorting and down-regulation of EGFR and also in HIV-1 budding.
