SUGT1 is homolog to yeast protein SGT1， a regulator of the cell cycle which is vital for G1/S and G2/M transitions. SUGT1 holds a CS domain， a SGS domain， a p23 domain and three tetratricopeptide repeats （TPR）. SUGT1 protein associates with Skp1 p19 and CUL-1， subunits of the SCF ubiquitin ligase complex， and is believed to take a part in protein degradation. Furthermore， SUGT1 is essential for the kinetochores assembly， and has a role as a co-chaperone for HSP90.
