N-myc-interactor belongs to the oncogene Myc family which has a significant part in cell proliferation， differentiation， and neoplastic transformation. In Addition， NMI cooperates with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA is expressed in small quantities in all human fetal and adult tissues tested except brain and but in large quantities in cancer cell line-myeloid leukemias.
