MAPRE1 （EB1） is a member of the intermediate/early gene family. MAPRE1 was first identified by its binding to the APC protein， which is often mutated in familial and sporadic， forms of colorectal cancer. MAPRE1 localizes to microtubules， especially the growing ends， in interphase cells. During mitosis， MAPRE1 is associated with the centrosomes and spindle microtubules. MAPRE1 is involved in microtubule polymerization， and spindle function by stabilizing microtubules and anchoring them at centrosomes.
