USP14 belongs to the ubiquitin-specific processing （UBP） family of proteases which is a deubiquitinating enzyme （DUB） containing His and Cys domains. USP14 placed in the cytoplasm and cuts the ubiquitin from ubiquitin-fused precursors and ubiquitinylated proteins.a mutation which results in reduced expression of the ortholog of USP14 in mice inhibits growth， develop severe tremors by 2 to 3 weeks of age followed by paralysis and death by 6 to 10 weeks of age.
