The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
应用类型
WB,IHC
免疫原
Synthetic peptide corresponding to residues near the C terminal of human ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
