Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis.Li L., J. Biol. Chem. 272:29403-29406(1997).Wong A.K.C., Genomics 59:248-251(1999).Gregory S.G., Nature 441:315-321(2006).
应用类型
WB
免疫原
Synthesized peptide derived from Internal of human CC14A.
