Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.Aebi M., Mol. Cell. Biol. 9:5062-5072(1989).Hattori M., Nature 405:311-319(2000).Mural R.J., Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
应用类型
WB
免疫原
Synthesized peptide derived from Internal of human MX2.
