Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development By similarity. Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells.Lucka L., FEBS Lett. 454:341-344(1999).Seppala R., Am. J. Hum. Genet. 64:1563-1569(1999).Huizing M., Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
应用类型
WB,IHC
免疫原
Synthesized peptide derived from C-terminal of human GNE.
