Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene By similarity. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.Zhuang D.Z., Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.The MGC Project Team, Genome Res. 14:2121-2127(2004).Hwang E.S., Immunology 106:464-469(2002).
应用类型
WB,IHC
免疫原
Synthesized peptide derived from internal of human ZC3H8.
