May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.Nagase T., DNA Res. 7:143-150(2000).The MGC Project Team, Genome Res. 14:2121-2127(2004).Ota T., Nat. Genet. 36:40-45(2004).
应用类型
IHC
免疫原
Synthesized peptide derived from internal of human USP36.
