Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.Wattenhofer M., Hum. Genet. 108:140-147(2001).Feshchenko E.A., Oncogene 23:4690-4706(2004).Hattori M., Nature 405:311-319(2000).
应用类型
WB
免疫原
Synthesized peptide derived from internal of human UBASH3A.
