This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. This sodium channel may be present in both denervated and innervated skeletal muscle.George A.L. Jr., Ann. Neurol. 31:131-137(1992).Wang J., Biochem. Biophys. Res. Commun. 182:794-801(1992).Tsujino A., Proc. Natl. Acad. Sci. U.S.A. 100:7377-7382(2003).
应用类型
WB
免疫原
Synthesized peptide derived from internal of human SCN4A.
