The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity By similarity. Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance By similarity.Mayer R.E., Biochemistry 30:3589-3597(1991) [PubMed: 1849734].Ota T., Nat. Genet. 36:40-45(2004) [PubMed: 14702039].Schmutz J., Nature 431:268-274(2004) [PubMed: 15372022].
应用类型
WB
免疫原
Synthesized peptide derived from internal of human PPP2R2B.
