Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6.Sasaki S., Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.Kalnine N., Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.Gregory S.G., Nature 441:315-321(2006).
应用类型
WB
免疫原
Synthesized peptide derived from Internal of human ARHGEF16.
