May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.Kourlas P.J., Proc. Natl. Acad. Sci. U.S.A. 97:2145-2150(2000).The MGC Project Team, Genome Res. 14:2121-2127(2004).Nagase T., DNA Res. 4:141-150(1997).
应用类型
WB
免疫原
Synthesized peptide derived from internal of human ARHGEF12.
