May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.Nagase T., DNA Res. 4:141-150(1997).Gregory S.G., Nature 441:315-321(2006).Ruemenapp U., FEBS Lett. 459:313-318(1999).
应用类型
WB
免疫原
Synthesized peptide derived from N-terminal of human ARHGEF11.
