Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.Farmer A., Submitted (MAY-2003).Wedegaertner P.B., J. Biol. Chem. 275:14992-14999(2000).Han D.K., Sci. Signal. 2:RA46-RA46(2009).
应用类型
WB
免疫原
Synthesized peptide derived from internal of human ARHGEF1.
