GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate.Furukawa Y., Biochem. Biophys. Res. Commun. 284:643-649(2001).The MGC Project Team, Genome Res. 14:2121-2127(2004).Kawasoe T., Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
应用类型
WB
免疫原
Synthesized peptide derived from internal of human RHG9.
