Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family.Cremers F.P.M., Hum. Mol. Genet. 1:71-75(1992).Kasper G., Gene 295:27-32(2002).Ota T. Nat. Genet. 36:40-45(2004)
应用类型
WB,IHC
免疫原
Synthesized peptide derived from internal of human CHML.
