Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells.Cao W., Am. J. Physiol. 283:C327-C337(2002).Nagase T., DNA Res. 5:355-364(1998).Nakajima D., DNA Res. 9:99-106(2002).
应用类型
WB
免疫原
Synthesized peptide derived from internal of human PPP1R16B.
