Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates By similarity.Ishikawa K., DNA Res. 5:169-176(1998).The MGC Project Team; Genome Res. 14:2121-2127(2004).Matsuoka S., Science 316:1160-1166(2007).
应用类型
WB
免疫原
Synthesized peptide derived from internal of human N4BP1.
