Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha By similarity. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4.Humphray S.J., Nature 429:369-374(2004).The MGC Project Team; Genome Res. 14:2121-2127(2004).Yokomizo T., J. Biol. Chem. 271:2844-2850(1996)
应用类型
WB
免疫原
Synthesized peptide derived from internal of human PTGR1.
