Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.Brower C.S., Proc. Natl. Acad. Sci. U.S.A. 99:10353-10358(2002).Gregory S.G., Nature 441:315-321(2006).Naeaer A.M., Nature 398:828-832(1999).
应用类型
WB
免疫原
Synthesized peptide derived from Internal of human MED8.
