ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.Staunton D.E., Nature 339:61-64(1989).Garcia-Aguilar J., Submitted (FEB-1990) to the EMBL/GenBank/DDBJ databases.Xu G., Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009).
应用类型
WB
免疫原
Synthesized peptide derived from internal of human ICAM2.
