Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.Hodgkinson J.E., Biochim. Biophys. Acta 1174:11-16(1993).Jabs E.W., Cell 75:443-450(1993).Iimura T., DNA Seq. 8:87-92(1997).
应用类型
WB
免疫原
Synthesized peptide derived from Internal of human MSX2.
