May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca2+ currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane By similarity. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.Reynet C., Science 262:1441-1444(1993).The MGC Project Team; Genome Res. 14:2121-2127(2004).Moyers J.S., J. Biol. Chem. 272:11832-11839(1997).
应用类型
WB,IHC,ICC
免疫原
Synthesized peptide derived from internal of human RAD.
