E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.Wang L., Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.Ota T., Nat. Genet. 36:40-45(2004).Kalnine N., Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
应用类型
WB
免疫原
Synthesized peptide derived from internal of human RNF138.
