E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity.Tateishi S., Proc. Natl. Acad. Sci. U.S.A. 97:7927-7932(2000).Xin H., Nucleic Acids Res. 28:2847-2854(2000).Muzny D.M., Nature 440:1194-1198(2006).
应用类型
WB
免疫原
Synthesized peptide derived from internal of human RAD18.
