Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.Hasegawa H., Mol. Cell. Biol. 16:1770-1776(1996).Deloukas P., Nature 429:375-381(2004).Matsuda M., J. Biol. Chem. 271:14468-14472(1996).
应用类型
WB
免疫原
Synthesized peptide derived from internal of human DOCK1.
