Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination By similarity.Kamei Y., J. Neurosci. Res. 51:275-283(1998).The MGC Project Team, Genome Res. 14:2121-2127(2004).Mayya V., Sci. Signal. 2:RA46-RA46(2009).
应用类型
WB
免疫原
Synthesized peptide derived from internal of human CNTN6.
