Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling.Kitagawa H., J. Biol. Chem. 276:38721-38726(2001).Nagase T., DNA Res. 6:63-70(1999).Clark H.F., Genome Res. 13:2265-2270(2003).
应用类型
WB,IHC
免疫原
Synthesized peptide derived from internal of human CHSY1.
