Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.Xu H., J. Biol. Chem. 273:17987-17990(1998).Mungall A.J., Nature 425:805-811(2003).The MGC Project Team; Genome Res. 14:2121-2127(2004).
应用类型
WB
免疫原
Synthesized peptide derived from internal of human FRS3.
