Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.Bertin J., J. Biol. Chem. 276:11877-11882(2001).Gaide O., FEBS Lett. 496:121-127(2001).Hillier L.W., Nature 424:157-164(2003).
应用类型
WB
免疫原
Synthesized peptide derived from internal of human CARD11.
