Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.Gregory S.G., Nature 441:315-321(2006).Guo Y., Proc. Natl. Acad. Sci. U.S.A. 99:3663-3667(2002).Ramsey H.C., Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
应用类型
WB,IHC
免疫原
Synthesized peptide derived from internal of human FOXD3.
