Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes.Momeni P., Nat. Genet. 24:71-74(2000).Chang G.T.G., J. Natl. Cancer Inst. 92:1414-1421(2000).Olsen J.V., Cell 127:635-648(2006).
应用类型
IHC
免疫原
Synthesized peptide derived from N-terminal of human TRPS1.
