Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation.Lai F., Genomics 66:65-75(2000).Hirosawa M., DNA Res. 6:329-336(1999).Ota T., Nat. Genet. 36:40-45(2004).
应用类型
WB,IHC,ICC
免疫原
Synthesized peptide derived from N-terminal of human KLHL3.
