Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.Chin M.T., J. Biol. Chem. 275:6381-6387(2000).Nakagawa O., Proc. Natl. Acad. Sci. U.S.A. 97:13655-13660(2000).Iso T., Mol. Cell. Biol. 21:6071-6079(2001).
应用类型
WB
免疫原
Synthesized peptide derived from internal of human HEY2.
