DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.Luo W.Q., Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.Favre C., Genes Immun. 4:40-45(2003).Cai D., J. Biol. Chem. 278:25323-25330(2003).
应用类型
WB
免疫原
Synthesized peptide derived from internal of human DOK5.
