Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B By similarity. Possesses a tumor suppressing activity in glioma cells.Van den Veyver I.B., J. Soc. Gynecol. Invest. 8:305-313(2001).Kohda T., Genes Cells 6:237-247(2001).Hiby S.E., Hum. Mol. Genet. 10:1093-1100(2001).
应用类型
WB
免疫原
Synthesized peptide derived from internal of human PEG3.
