Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation By similarity. UniProtKB Q9JHE6Bae S.-K., Development 127:2933-2943(2000).Vasiliauskas D., Mech. Dev. 98:133-137(2000).Ota T., Nat. Genet. 36:40-45(2004).
应用类型
WB
免疫原
Synthesized peptide derived from N-terminal of human HES6.
